Mechanisms of apoptotic phosphatidylserine exposure
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چکیده
منابع مشابه
Brief Definitive Report Mechanisms of Phosphatidylserine Exposure, A Phagocyte Recognition Signal, on Apoptotic T Lymphocytes
The appearance of phosphatidylserine (PS) on the cell surface during apoptosis in thymocytes and cytotoxic T lymphocyte cell lines provokes PS-dependent recognition by activated macrophages. Flow cytometric analysis o f transbilayer lipid movements in T lymphocytes undergoing apoptosis reveals that downregulation of the adenosine tr iphosphate-dependent aminophospholipid translocase and activat...
متن کاملMechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes
The appearance of phosphatidylserine (PS) on the cell surface during apoptosis in thymocytes and cytotoxic T lymphocyte cell lines provokes PS-dependent recognition by activated macrophages. Flow cytometric analysis of transbilayer lipid movements in T lymphocytes undergoing apoptosis reveals that downregulation of the adenosine triphosphate-dependent amino-phospholipid translocase and activati...
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Xk-related protein (Xkr) 8, a protein carrying 10 transmembrane regions, is essential for scrambling phospholipids during apoptosis. Here, we found Xkr8 as a complex with basigin (BSG) or neuroplastin (NPTN), type I membrane proteins in the Ig superfamily. In BSG(-/-)NPTN(-/-) cells, Xkr8 localized intracellularly, and the apoptosis stimuli failed to expose phosphatidylserine, indicating that B...
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Platelets are known to participate in all phases of haemostasis in vivo. Besides the obvious contribution in formation of the platelet plug, they provide the surface necessary for the assembly of the tenase and prothrombinase complexes, a process leading to the formation of thrombin, and ultimately the fibrin clot. The complex assembly involves the translocation of negatively charged phosphatid...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2013
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2013.115